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Home Antibody All anti-IKBKAP antibodies

Anti-IKBKAP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306056
  • Rabbit Polyclonal IKAP Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418524) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for IKBKAP (NM_003640)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIKAP antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 1 ug/ml, ICC: 1 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP)
Alternative NameDYS; ELP1; FD; IKAP; IKI3; TOT1
Database LinkNP_003631
Entrez Gene 8518 Human
Entrez Gene 230233 Mouse
FunctionIKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKalpha, IKKbeta, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IKAP in A-20 cell lysate with IKAP antibody at in (A) 0.5, and (B) 1 ug/mL.
IF Image
Immunocytochemistry of IKAP in A-20 cells with IKAP antibody at 1 ug/mL.

 

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