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Home Antibody All anti-PYCARD antibodies

Anti-PYCARD Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306044
  • Rabbit Polyclonal ASC Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402233) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for PYCARD (NM_013258)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenASC antibody was raised against a synthetic peptide corresponding to amino acids 182 to 195 of human ASC .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens PYD and CARD domain containing (PYCARD), transcript variant 1
Alternative NameASC; CARD5; TMS; TMS-1; TMS1
Database LinkNP_037390
FunctionApoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 (1-3). Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3,4). Overexpression of ASC/TMS1 induced DNA fragmentation (4). ASC/TMS1 is expressed in a variety of human and mouse tissues (1, 2)
Related Pathway

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WB Image
Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide (2287P) with ASC antibody at 1 ug /ml.
IF Image
Immunocytochemistry of ASC in HL60 cells with ASC antibody at 5 ug/mL.

 

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