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Home Antibody All anti-NPHS1 antibodies

Anti-NPHS1 Antibody


Specifications Citations (2) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306037 Rabbit Polyclonal Nephrin Antibody 100ug $325 In Stock
LC417848 NPHS1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenNephrin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Nephrin.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/mL, ICC: 1 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nephrosis 1, congenital, Finnish type (nephrin) (NPHS1)
Alternative NameCNF; nephrin; NPHN
Database LinkNP_004637
Entrez Gene 4868 Human
Entrez Gene 54631 Mouse
Entrez Gene 64563 Rat
FunctionNephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm. Despite its predicted molecular weight, Nephrin often migrates at a lower than expected size in SDS-PAGE.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Nephrin in mouse kidney tissue lysate with Nephrin antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.

WB Image
Figure from citation: Western Blot of NPHS1(Nephrin) protein level by using anti-NPHS1 antibody in cell lysates of quiescent mouse podocytes. View Citation

IHC Image
Immunohistochemistry of Nephrin in mouse kidney tissue with Nephrin antibody at 1 ug/ml.

IF Image
Immunofluorescence of Nephrin in Mouse Kidney cells with Nephrin antibody at 10 ug/mL.


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