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Home Antibody All anti-SKIL antibodies

Anti-SKIL Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306034
  • Rabbit Polyclonal SnoN Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for SKIL (NM_001145097)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSnoN antibody was raised against a 16 amino acid peptide from near the amino terminus of human SnoN .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens SKI-like oncogene (SKIL), transcript variant 2
Alternative NameSNO; SnoA; SnoI; SnoN
Database LinkNP_001138569
FunctionTGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
Related Pathway
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of SnoN in A431 cell lysate with SnoN antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of SnoN in mouse lung tissue with SnoN antibody at 5 ug/ml.

 

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