Home Antibody All anti-BACE2 antibodies
Also for BACE2 (NM_012105)
|BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a|
|AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP|
Entrez Gene 25825 Human
|Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the β-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought β-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)|
|TransmembraneProteaseDruggable Genome Alzheimer's disease|
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Western blot analysis of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with BACE2 antibody at 1 ug/ml.
Immunohistochemistry of BACE2 in rat heart tissue with BACE2 antibody at 2 ug/ml.