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Home Antibody All anti-BACE2 antibodies

Anti-BACE2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306032 Rabbit Polyclonal BACE2 Antibody 100ug $325 3-7 Days
LC415975 BACE2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for BACE2 (NM_012105)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenBACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a
Alternative NameAEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
Database LinkNP_036237
Entrez Gene 25825 Human
FunctionAccumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the β-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought β-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)
Related PathwayTransmembraneProteaseDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with BACE2 antibody at 1 ug/ml.
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Immunohistochemistry of BACE2 in rat heart tissue with BACE2 antibody at 2 ug/ml.
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