Home Antibody All anti-BACE2 antibodies
Also for BACE2 (NM_012105)
|BACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a|
|AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP|
Entrez Gene 25825 Human
Entrez Gene 56175 Mouse
Entrez Gene 288227 Rat
|Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)|
|TransmembraneProteaseDruggable Genome Alzheimer's disease|
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Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml.
Immunohistochemistry of BACE2 in mouse heart with BACE2 antibody at 10 ug/ml.