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|Caspase-13 antibody was raised against a peptide corresponding to amino acids 91 to 105 of human caspase-13.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha|
|ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX|
|Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13?(1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).|
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Western blot analysis of caspase-13 in human HL60 cell lysate (A), mouse brain (B) and rat brain (C) tissue lysates with caspase-13 antibody at 1 ug/ml.
Immunohistochemistry of Caspase-13 in mouse brain tissue with Caspase-13 antibody at 10 ug/ml.