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Anti- Antibody

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SKU Description Amount Price Availability*  
TA306030
  • Rabbit Polyclonal Caspase-13 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400489) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenCaspase-13 antibody was raised against a peptide corresponding to amino acids 91 to 105 of human caspase-13.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha
Alternative NameICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX
Database LinkNP_001216
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13?(1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).
Related Pathway
Apoptosis

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WB Image
Western blot analysis of caspase-13 in human HL60 cell lysate (A), mouse brain (B) and rat brain (C) tissue lysates with caspase-13 antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of Caspase-13 in mouse brain tissue with Caspase-13 antibody at 10 ug/ml.

 

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