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Home Antibody All anti-NOL3 antibodies

Anti-NOL3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306023
  • Rabbit Polyclonal Nop30 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401296) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for NOL3 (NM_003946)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNop30 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Nop30 .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), transcript variant 2
Alternative NameARC; FCM; MYP; NOP; NOP30
Database LinkNP_003937
Entrez Gene 8996 Human
Entrez Gene 78688 Mouse
Entrez Gene 85383 Rat
FunctionApoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and the caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. An alternate splicing isoform of ARC was identified as Nop30. While ARC interacts with caspase-2 and –8 and suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3, Nop30 multimerizes and binds to the splicing factor SRp30c and may act to influence alternative splice site selection in vivo. The Nop30 antibody will not detect ARC protein.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Nop30 in mouse muscle tissue lysate with Nop30 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml.

 

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