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Home Antibody All anti-BCL10 antibodies

Anti-BCL10 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306011 Rabbit Polyclonal Bcl-10 Antibody 100ug $325 3-7 Days
LC418351 BCL10 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenBcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 ug/ml, ICC: 1 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens B-cell CLL/lymphoma 10 (BCL10)
Alternative Namec-E10; CARMEN; CIPER; CLAP; IMD37; mE10
Database LinkNP_003912
Entrez Gene 8915 Human
Entrez Gene 12042 Mouse
Entrez Gene 83477 Rat
FunctionApoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kappaB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation . Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy . Bcl10 is expressed in many human and murine tissues and cell lines.
Related PathwayDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution.
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Immunocytochemistry of Bcl10 in Raji cells with Bcl10 antibody at 1 ug/mL.
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