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Home Antibody All anti-IL1RAP antibodies

Anti-IL1RAP Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306000
  • Rabbit Polyclonal IL-1RAcP Antibody
100ug 325 3-7 Days
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WB(1)
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Also for IL1RAP (NM_001167928)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenIL-1RAcP antibody was raised against a peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin 1 receptor accessory protein (IL1RAP), transcript variant 3
Alternative NameC3orf13; IL-1RAcP; IL1R3
Database LinkNP_001161400
Entrez Gene 3556 Human
FunctionThe pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) (1). IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NFkappa-B inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP (2). IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP (3,4). Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IL-1RAcP in HeLa whole cell lysate with IL-1RAcP antibody (C2) at 1:1000 dilution.

 

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