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Home Antibody All anti-CX3CR1 antibodies

Anti-CX3CR1 Antibody


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305989 Rabbit Polyclonal CX3CR1 Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenCX3CR1 antibody was raised against a peptide corresponding to amino acids 2 to 21 of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3,4).
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 1 ug/mL, IHC: 2 ug/mL, IF: 10 ug/mL, FACS: 0.1 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens chemokine (C-X3-C motif) receptor 1 (CX3CR1), transcript variant 2
Alternative NameCCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28
Database LinkNP_001164642
Entrez Gene 1524 Human
Entrez Gene 13051 Mouse
Entrez Gene 171056 Rat
FunctionCX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).
Related PathwayGPCRTransmembraneDruggable Genome Cytokine-cytokine receptor interactionChemokine signaling pathway

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WB Image
Western blot analysis of CX3CR1 in human spleen lysate with CX3CR1 antibody in the absence (lane 1) or presence of blocking peptide (lane 2).

IHC Image
Immunohistochemical staining of human heart tissue using CX3CR1 antibody at 2 ug/ml

IF Image
Immunofluorescence of CX3CR1 in Human Heart cells with CX3CR1 antibody at 10 ug/mL.


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