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Home Antibody All anti-RIPK2 antibodies

Anti-RIPK2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305984 Rabbit Polyclonal RICK Antibody 100ug $325 In Stock
LC418408 RIPK2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for RIPK2 (NM_003821)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2)
Alternative NameCARD3; CARDIAK; CCK; GIG30; RICK; RIP2
Database LinkNP_003812
Entrez Gene 8767 Human
Entrez Gene 192656 Mouse
Entrez Gene 362491 Rat
FunctionApoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues.
Related PathwayProtein KinaseDruggable Genome NOD-like receptor signaling pathwayNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 ug/mL.


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