Home Antibody All anti-RIPK2 antibodies
Also for RIPK2 (NM_003821)
|RICK antibody was raised against a peptide corresponding to amino acids near the amino terminus of human RICK.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens receptor-interacting serine-threonine kinase 2 (RIPK2)|
|CARD3; CARDIAK; CCK; GIG30; RICK; RIP2|
Entrez Gene 8767 Human
Entrez Gene 192656 Mouse
Entrez Gene 362491 Rat
|Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively, (1-3). RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1b. The messenger RNA of RICK is expressed in multiple human tissues.|
|Protein KinaseDruggable Genome NOD-like receptor signaling pathwayNeurotrophin signaling pathway|
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Western blot analysis of RICK in A431 (A) and K562 (K) whole cell lysate with RICK antibody at 1:1000 dilution.
Immunocytochemistry of RICK in A431 cells with RICK antibody at 10 ug/mL.