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Home Antibody All anti-CASP9 antibodies

Anti-CASP9 Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305983 Rabbit Polyclonal Caspase-9 Antibody 100ug $325 3-7 Days
LC400491 CASP9 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(2)
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Also for CASP9 (NM_001229)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Assay

OriGene Data

ImmunogenCaspase-9 antibody was raised against a peptide corresponding to amino acids 299 to 318 of human caspase-9 .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha
Alternative NameAPAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56
Database LinkNP_001220
Entrez Gene 842 Human
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (1-3). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (3). Caspase-9 is also activated by granzyme B and CPP32 (1,2). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD (4). Caspase-9 is expressed in a variety of human tissues (1,2).
Related PathwayProteaseStem cell - PluripotencyDruggable Genome p53 signaling pathwayApoptosisVEGF signaling pathwayAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)More Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of caspase-9 in HeLa whole cell lysate with Caspase-9 antibody at 1:1000 dilution
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IF Image
Immunocytochemistry staining of K562 cells using Caspase-9 antibody at 2 ug/mL.
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IF Image
Immunofluorescence of Caspase-9 in K562 cells with Caspase-9 antibody at 20 ug/mL.
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