Home Antibody All anti-TNFRSF10D antibodies
Also for TNFRSF10D (NM_003840)
|DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of human DcR2 precursor.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1:1000, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D)|
|CD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD|
Entrez Gene 8793 Human
|Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity|
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Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1:1000 dilution.
Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10ug/mL.