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Home Antibody All anti-TNFRSF10D antibodies

Anti-TNFRSF10D Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305975
  • Rabbit Polyclonal DcR2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401258) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IF(1)
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Also for TNFRSF10D (NM_003840)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenDcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of human DcR2 precursor.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1:1000, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D)
Alternative NameCD264; DCR2; TRAIL-R4; TRAILR4; TRUNDD
Database LinkNP_003831
Entrez Gene 8793 Human
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1:1000 dilution.
IF Image
Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10ug/mL.

 

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