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Home Antibody All anti-TNFRSF10B antibodies

Anti-TNFRSF10B Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305974 Rabbit Polyclonal DR5 Antibody 100ug $325 In Stock
LC401260 TNFRSF10B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for TNFRSF10B (NM_003842)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenDR5 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 2 ug/mL, ICC: 5 ug/mL, IF: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1
Database LinkNP_003833
Entrez Gene 8795 Human
Entrez Gene 21933 Mouse
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicity

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.

IF Image
Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.

IF Image
Immunofluorescence of DR5 in HeLa cells with DR5 antibody at 20 ug/mL.


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