OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-TNFRSF10B antibodies

Anti-TNFRSF10B Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305974
  • Rabbit Polyclonal DR5 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401260) , 20ug
100ug 325 In Stock
Add to Shopping Cart
WB(1)
IF(1)
spacer
Also for TNFRSF10B (NM_003842)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenDR5 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 ug/ml, ICC: 5 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1
Alternative NameCD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
Database LinkNP_003833
FunctionApoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.
Related Pathway
Apoptosis
Cytokine-cytokine receptor interaction

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
IF Image
Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title