Home Antibody All anti-TNFRSF10B antibodies
Also for TNFRSF10B (NM_003842)
|DR5 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor .|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 2 ug/ml, ICC: 5 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1|
|CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9|
Entrez Gene 8795 Human
Entrez Gene 21933 Mouse
|Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionp53 signaling pathwayApoptosisNatural killer cell mediated cytotoxicity|
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Western blot analysis of DR5 in HeLa (H) and K562 (K) cell lysates with DR5 antibody at 2 ug/mL.
Immunocytochemistry of DR5 in HeLa cells with DR5 antibody at 5 ug/mL.