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Home Antibody All anti-CFLAR antibodies

Anti-CFLAR Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305963
  • Rabbit Polyclonal FLIP Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426693) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IF(1)
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Also for CFLAR (NM_001127183)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFLIP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human FLIPaFLIPl form.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 2
Alternative Namec-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
Database LinkNP_001120655
Entrez Gene 8837 Human
Entrez Gene 12633 Mouse
Entrez Gene 117279 Rat
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively1,2. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively (8).
Related PathwayProteaseDruggable Genome Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of FLIP in HeLa (H), Jurkat (J), and K562 (K) whole cell lysate with FLIP antibody at 1:1000 dilution.
IF Image
Immunocytochemistry of FLIP in Jurkat cells with FLIP antibody at 10 ug/mL.

 

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