Home Antibody All anti-Cflar antibodies
Also for Cflar (NM_009805)
|FLIP antibody was raised against a peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa.|
||ELISA, WB: 0.5 ug/ml, ICC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Mus musculus CASP8 and FADD-like apoptosis regulator (Cflar), transcript variant 2|
|2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip;|
Entrez Gene 12633 Mouse
|Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family.Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH, CLARP and MRIT. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1.|
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Western blot analysis of FLIP in NIH/3T3 whole cell lysate with FLIP antibody at 1:500 dilution.
Immunocytochemistry of FLIP in 3T3 cells with FLIP antibody at 5 ug/mL.