Home Antibody All anti-CASP10 antibodies
Also for CASP10 (NM_001230)
|Caspase-10 antibody was raised against a peptide corresponding to amino acids 505 to 521 of human FLICE2.|
||WB: 1:500 - 1:1000
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens caspase 10, apoptosis-related cysteine peptidase (CASP10), transcript variant 3|
|ALPS2; FLICE2; MCH4|
|Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch41,2 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis1. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.|
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Western blot analysis of caspase-10 in HeLa (H), Jurkat (J), A431 (A), K562 (K) whole cell lysates with Caspase-10 antibody at 1 µg/ml.