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Home Antibody All anti-NRTN antibodies

Anti-NRTN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305946
  • Rabbit Polyclonal Neurturin Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417904) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NRTN (NM_004558)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogenneurturin antibody was raised against a peptide corresponding to amino acids 178 to 193 of human neurturin .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 5ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens neurturin (NRTN)
Alternative NameNTN
Database LinkNP_004549
FunctionGlial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently (3-8) and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-Β-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. NTN binds to and forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
Related Pathway

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WB Image
Western blot analysis of NTN in HeLa cell lyaste containing 10 or 2.5 ng of full length recombinant NTN with neurturin antibody at 1:500.
IHC Image
Immunohistochemistry of neurturin in human brain tissue with neurturin antibody at 5 ug/ml.

 

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