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Also for STAT1 (NM_007315)
|STAT1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human STAT1 alpha The sequences differ from the murine corresponding sequences by four amino acids.|
|Human, Mouse, Rat
||ELISA, WB: 1:1000 - 1:2000, ICC: 10 ug/ml, IP: 2 - 4 ug/sample
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha|
|CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91|
Entrez Gene 6772 Human
Entrez Gene 20846 Mouse
Entrez Gene 25124 Rat
|STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5alpha, and Stat5beta have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN-beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta which are encoded by the same gene with splicing variant.|
|Transcription FactorsDruggable Genome Chemokine signaling pathwayToll-like receptor signaling pathwayJak-STAT signaling pathwayPathways in cancerPancreatic cancer|
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Western blot analysis of STAT1 alpha in whole cell lysates from HeLa (H), Jurkat (J), A431 (A), K562 (K), and NIH3T3 (N) cells, with STAT1a antibody at 1 ug/mL.
Immunocytochemistry of STAT1 alpha in HeLa cells with STAT1 alpha antibody at 10 ug/mL.