Home Antibody All anti-IRAK1 antibodies
Also for IRAK1 (NM_001025242)
|IRAK antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IP: 2 - 4 ug/sample, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified (Protein A or G Sepharose)
|Homo sapiens interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 2|
|Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).|
Toll-like receptor signaling pathway
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Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with IRAK antibody at 1:2000
Immunohistochemistry of IRAK in HeLa cells with IRAK antibody at 10 ug/ml.