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Anti-IRAK1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305934 Rabbit Polyclonal IRAK Antibody 100ug $325 3-7 Days
LC422494 IRAK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenIRAK antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IP: 2 - 4 ug/sample, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 2
Alternative NameIRAK; pelle
Database LinkNP_001020413
Entrez Gene 3654 Human
Entrez Gene 16179 Mouse
Entrez Gene 363520 Rat
FunctionNuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Related PathwayProtein KinaseTranscription FactorsDruggable Genome ApoptosisToll-like receptor signaling pathwayNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with IRAK antibody at 1:2000
Immunohistochemistry of IRAK in HeLa cells with IRAK antibody at 10 ug/ml.


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