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Home Antibody All anti-GRN antibodies

Anti-GRN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305781
  • Goat Anti-Granulin / GRN Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419545) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenPeptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.
Clone Name IsotypeGoat IgG
Species ReactivityHuman Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1-3ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens granulin (GRN), transcript variant 2
Alternative NameGEP, GP88, PEPI, PGRN, PCDGF;GEP; GP88; PCDGF; PEPI; PGRN; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin; granulin
Database LinkNP_001012497
FunctionGranulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq].
Related Pathway

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WB Image
TA305781 (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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