Home Antibody All anti-ACO1 antibodies
Also for ACO1 (NM_002197)
|Peptide with sequence C-QVDFNRRADSLQKNQ, from the internal region of the protein sequence according to NP_002188.1.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Cow
|0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
|Homo sapiens aconitase 1, soluble (ACO1), transcript variant 2|
|ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1|
Entrez Gene 48 Human
Entrez Gene 11428 Mouse
Entrez Gene 50655 Rat
|Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]. |
|Druggable Genome Citrate cycle (TCA cycle)Glyoxylate and dicarboxylate metabolismMetabolic pathways|
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TA305638 (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.