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Home Antibody All anti-CYBB antibodies

Anti-CYBB Antibody


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SKU Description Amount Price Availability*  
TA305618 Goat Anti-CYBB / GP91-PHOX Antibody 100ug $325 In Stock
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OriGene Data

ImmunogenPeptide with sequence C-SYLNFARKRIKNP, from the internal region of the protein sequence according to NP_000388.2.
Clone Name IsotypeGoat IgG
Species ReactivityTested: Human. Expected from sequence similarity: Human, Dog Concentration0.5 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.03-0.1 µg/ml. IHC: 2-4 µg/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens cytochrome b-245, beta polypeptide (CYBB)
Alternative NameAMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
Database LinkNP_000388
Entrez Gene 1536 Human
Entrez Gene 491825 Dog
FunctionCytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq].
Related PathwayIon Channels: OtherTransmembraneDruggable Genome Leukocyte transendothelial migration

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
TA305618 (0.03 ug/ml) staining of Human Peripheral Blood Mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

IHC Image
TA305618 (2 ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.


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