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Home Antibody All anti-DAG1 antibodies

Anti-DAG1 Antibody EP2200Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303855
  • Rabbit monoclonal antibody against DAG1(EP2200Y )
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding o residues near the C-terminus of human ?-Dystroglycan was used as an immunogen.
Clone NameEP2200Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), transcript variant 2
Alternative Name156DAG; A3a; AGRNR; DAG; MDDGC7; MDDGC9
Database LinkNP_004384
FunctionDystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq].
Related Pathway

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WB Image
Western blot - beta Dystroglycan antibody [EP2200Y]; Anti-beta Dystroglycan antibody [EP2200Y] at 1/2000 dilution + human brain lysate at 10 µg.Secondary.Goat anti-rabbit, HRP labeled, at 1/2000 dilution

 

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