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Home Antibody All anti-NEFM antibodies

Anti-NEFM PHOSPHO Antibody EPR580(2)Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303832
  • Rabbit monoclonal antibody against Neurofilament M Phospho (pS614/619) (EPR580(2)Y ) (phospho-specific)
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for NEFM (NM_005382)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 614/619 of human NF-M was used as an immunogen.
Clone NameEPR580(2)Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:100 - 250; IP: 1:30
Predicted MW Explanation 102 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens neurofilament, medium polypeptide (NEFM), transcript variant 1
Alternative NameNEF3; NF-M; NFM
Database LinkNP_005373
Entrez Gene 4741 Human
FunctionNeurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Related Pathway Amyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-160 kD Neurofilament Medium (phospho S614 + S619) antibody [EPR580(2)Y]; All lanes : Anti-160 kD Neurofilament Medium (phospho S614 + S619) antibody [EPR580(2)Y] at 1/500 dilution.Lane 1 : SH-SY5Y cell lysate treated with Alkaline phosphatase.Lane 2 : Untreated SH-SY5Y cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 102 kDa.Observed band size : 160 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - 160 kD Neurofilament Medium (phospho S614 + S619) antibody [EPR580(2)Y]; Immunohistochemical analysis of paraffin-embedded human brain tissue using TA303832 at a dilution of 1/100 - 1/250

 

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