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Anti-PRKCB Antibody Y125
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Also for PRKCB (NM_002738)
|A synthetic peptide corresponding to residues near C-terminus of human PKC beta-II was used as immunogen. The antibody does not cross-react with human PKC beta-I. Predicted to cross-react with mouse and bovine PKC beta, rat and pig PKC beta-II, based on s|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1:500; IHC: 1:100-250; ICC: 1:250-500; FC: 1:50; IP: 1:60
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2|
|PKC-beta; PKCB; PRKCB1; PRKCB2|
|Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. |
EGFR1 Signaling Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis on K562 cell lysate using anti-PKCβII RabMAb (TA303830), dilution 1:500
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti- PKCβII RabMAb (TA303830).
Immunofluorescent staining of HeLa cells using anti-PKCβII RabMAb (TA303830).