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Home Antibody All anti-PLCG2 antibodies

Anti-PLCG2 PHOSPHO Antibody EP1405Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303824
  • Rabbit monoclonal antibody against PLCyII Phospho (pY1197) (EP1405Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for PLCG2 (NM_002661)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 1197 of human PLC?II was used as an immunogen. This antibody detects PLC?II phosphorylated on tyrosine 1197.
Clone NameEP1405Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2000 - 1:20000; IP: 1:40; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IHC-P.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2)
Alternative NameAPLAID; FCAS3; PLC-gamma-2; PLC-IV
Database LinkNP_002652
Entrez Gene 5336 Human
FunctionEnzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM].
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PLCG 2 (phospho Y1197) antibody [EP1405Y]; All lanes : Anti-PLCG 2 (phospho Y1197) antibody [EP1405Y] at 1/20000 dilution.Lane 1 : Raji cell lysates un-treated.Lane 2 : Raji cell lysates treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 150 kDa .

 

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