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Anti-LRP6 PHOSPHO Antibody EP2360Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against LRP6 Phospho (pS1490) (EP2360Y ) (phospho-specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 1490 of human LRP6 was used as an immunogen. This antibody detects LRP6 phosphorylated on serine 1490.
Clone NameEP2360Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1000; ICC: 1:100 - 250
Predicted MW Explanation 179 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens low density lipoprotein receptor-related protein 6 (LRP6)
Alternative NameADCAD2
Database LinkNP_002327
Entrez Gene 4040 Human
FunctionThe LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM].
Related PathwayTransmembraneDruggable Genome Wnt signaling pathway

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Western blot - LRP6 (phospho S1490) antibody [EP2360Y]; All lanes : Anti-LRP6 (phospho S1490) antibody [EP2360Y] at 1/1000 dilution.Lane 1 : HeLa cell lysates, untreated.Lane 2 : HeLa cell lysates treated with Calyculin.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 179 kDa.Observed band size : 210 kDa .


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