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Anti-LRP6 PHOSPHO Antibody EP2360Y
Also for LRP6 (NM_002336)
|A phospho specific peptide corresponding to residues surrounding serine 1490 of human LRP6 was used as an immunogen. This antibody detects LRP6 phosphorylated on serine 1490.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1000; ICC: 1:100 - 250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6)|
|The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM]. |
Wnt Signaling Pathway
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Western blot - LRP6 (phospho S1490) antibody [EP2360Y]; All lanes : Anti-LRP6 (phospho S1490) antibody [EP2360Y] at 1/1000 dilution.Lane 1 : HeLa cell lysates, untreated.Lane 2 : HeLa cell lysates treated with Calyculin.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 179 kDa.Observed band size : 210 kDa .