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Anti-TIRAP Antibody EP1231Y
Also for TIRAP (NM_001039661)
|A synthetic peptide corresponding to residues near the N-terminus of human TIRAP was used as an immunogen. This antibody detects 3 different isoforms of TIRAP.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000; IHC: 1:100 - 250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3|
|BACTS1; Mal; MyD88-2; wyatt|
|The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq]. |
Toll-like receptor signaling pathway
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Western blot - TIRAP antibody [EP1231Y]; Anti-TIRAP antibody [EP1231Y] at 1/1000 dilution + HeLa cell lysate at 10 µg.Predicted band size : 24-30 kDa.Observed band size : 30 kDa .Additional bands at : 24 kDa,27 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Paraffin-embedded sections) - TIRAP antibody [EP1231Y]; Immunohistochemical staining of TIRAP in paraffin embedded human liver tissue using ab52911 at 1/100 dilution.