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Anti-SIRT1 Phospho Antibody EP2850Y
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Also for SIRT1 (NM_012238)
|A phospho-specific peptide corresponding to residues surrounding serine 27 of human Sir2/SIRT1 was used as an immunogen. This antibody detects Sir2/SIRT1 phosphorylated on serine 27.|
||WB: 1:5000 -10,000; IP: 1:20
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens sirtuin 1 (SIRT1), transcript variant 1|
|This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. |
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Western blot analysis on 293T cell lysates using anti-Phospho-Sir2/SIRT1 (pS27) RabMAb (TA303786), 1:10,000 dilution. Cells were either (A) untreated (B) treated with Calyculin A.