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Anti-NCSTN Antibody EPR2575Y
Also for NCSTN (NM_015331)
|A synthetic peptide corresponding to residues on the C-terminus of human Nicastrin was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000; FC: 1:20; IP: 1:40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Homo sapiens nicastrin (NCSTN), transcript variant 1|
|This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq]. |
Delta-Notch Signaling Pathway
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Western blot - Nicastrin antibody [EPR2575Y]; All lanes : Anti-Nicastrin antibody [EPR2575Y] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HL-60 cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 78 kDa.Additional bands at : 100-120 kDa (possible isoform),130-160 kDa (possible isoform).