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Home Antibody All anti-NCSTN antibodies

Anti-NCSTN Antibody EPR2575Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303782
  • Rabbit monoclonal antibody against Nicastrin (EPR2575Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414628) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for NCSTN (NM_015331)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human Nicastrin was used as an immunogen.
Clone NameEPR2575Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000; FC: 1:20; IP: 1:40
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens nicastrin (NCSTN), transcript variant 1
Alternative NameATAG1874
Database LinkNP_056146
FunctionThis gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq].
Related Pathway
Delta-Notch Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Nicastrin antibody [EPR2575Y]; All lanes : Anti-Nicastrin antibody [EPR2575Y] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HL-60 cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 78 kDa.Additional bands at : 100-120 kDa (possible isoform),130-160 kDa (possible isoform).</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>

 

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