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[anti-HA]
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[Akt3]
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[LA]
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[JAK2]
Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1
Synonyms:
SRK; STCD; STD; TZK; ZAP-70
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr492 of human ZAP-70 was used as immunogen. The antibody only detects ZAP-70 phosphorylated on Tyrosine 492.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway
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Western blot analysis on Jurkat cell lysates using anti-Phospho-ZAP-70 (p492) RabMAb (TA303739), 1:20,000 dilution. Cells were either (A) untreated (B) treated with pervanadate</div>
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