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Anti-ZAP70 PHOSPHO Antibody EP2291Y
Also for ZAP70 (NM_001079)
|A synthetic phospho-peptide corresponding to residues surrounding Tyr492 of human ZAP-70 was used as immunogen. The antibody only detects ZAP-70 phosphorylated on Tyrosine 492.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:20000; IP: 1:30
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1|
|SRK; STCD; STD; TZK; ZAP-70|
Entrez Gene 7535 Human
|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]. |
|Protein KinaseDruggable Genome Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayPrimary immunodeficiency|
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Western blot - ZAP70 (phospho Y492) antibody [EP2291Y]; All lanes : Anti-ZAP70 (phospho Y492) antibody [EP2291Y] at 1/20000 dilution.Lane 1 : Jurkat cell lysates, untreated.Lane 2 : Jurkat cell lysates, treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 70 kDa.Observed band size : 70 kDa.