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Anti-ZAP70 Antibody E267
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Also for ZAP70 (NM_001079)
|A synthetic peptide corresponding to residues in N-terminus of human ZAP-70 was used as immunogen.|
|Human, Mouse, Rat
||WB: 1:500; FC: 1:40; IP: 1:30
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1|
|SRK; STCD; STD; TZK; ZAP-70|
|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]. |
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Western blot analysis on Jurkat cell lysate using anti-ZAP-70 RabMAb (TA303737); dilution 1:500.