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Home Antibody All anti-WAS antibodies

Anti-WAS Antibody EPR2540Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303735
  • Rabbit monoclonal antibody against WASP (EPR2540Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424761) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for WAS (NM_000377)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human WASP was used as an immunogen.
Clone NameEPR2540Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 2000; IHC: 1:100; FC: 1:30; IP: 1:30
Predicted MW Explanation 53 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens Wiskott-Aldrich syndrome (WAS)
Alternative NameIMD2; SCNX; THC; THC1; WASP
Database LinkNP_000368
Entrez Gene 7454 Human
Entrez Gene 22376 Mouse
Entrez Gene 317371 Rat
FunctionThe Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq].
Related PathwayDruggable Genome Chemokine signaling pathwayAdherens junctionFc gamma R-mediated phagocytosisRegulation of actin cytoskeletonPathogenic Escherichia coli infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - WASP antibody [EPR2540Y]; All lanes : Anti-WASP antibody [EPR2540Y] at 1/2000 dilution.Lane 1 : TF1 cell lysate.Lane 2 : U937 cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 55 kDa .

 

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