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Anti-TYK2 Antibody EP1127Y
Also for TYK2 (NM_003331)
|A synthetic peptide corresponding to residues near the C-terminus of human Tyk2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:50000; IP: 1:50; ICC/IF: 1:100 - 1:250; IHC-P: Use at an assay dependent dilution
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens tyrosine kinase 2 (TYK2)|
|This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq]. |
Jak-STAT signaling pathway
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Western blot - TYK2 antibody [EP1127Y]; Anti-TYK2 antibody [EP1127Y] at 1/50000 dilution + Raji cell lysate at 10 µg.Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 134 kDa.Observed band size : 140 kDa .
Immunohistochemistry (Paraffin-embedded sections) - TYK2 antibody [EP1127Y]; ab52645 (1/100) staining TYK2 in paraffin embedded human liver tissue by Immunohistochemistry.