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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody E47

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303724
  • Rabbit monoclonal antibody against p53 (C-Term)(E47)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400186) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for TP53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to C-terminal residues human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.
Clone NameE47 IsotypeRabbit IgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000; ICC: 1:100; FC: 1:50; IP: 1:50
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
FunctionThis gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq].
Related Pathway
Apoptosis
Cell cycle
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p53 antibody [E47]; Anti-p53 antibody [E47] at 1/1000 dilution + A431 lysate.Predicted band size : 44 kDa.Observed band size : 53 kDa .</title><style>.awu3{position:absolute;clip:rect(403px,auto,auto,403px);}</style><div class=awu3>Is there was that <a href=http://paydayloansforus.com >payday loan lender</a> improve your payday loan.</div>

 

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