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Anti-TOP2A Phospho Antibody EP2722
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Also for TOP2A (NM_001067)
|A phospho specific peptide corresponding to residues surrounding Serine 1106 of human Topoisormera II alpha was used as an immunogen. This antibody detects Topoisomerase II alpha phosphorylated on Serine 1106.|
||WB: 1:1:500; IHC: 1:100 -250; ICC: 1:100 -250
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)|
|This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq]. |
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Western blot analysis on HeLa cell lysates using anti-Phospho-Topoisomerase II alpha (pS1106) RabMAb (TA303723), 1:500 dilution. Cells were either (A) untreated (B) treated with AP
Immunohistochemical analysis of colonic adenocarcinoma using Phospho-anti-Topoisomerase II alpha RabMAb (TA303723).