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Anti-RAF1 Antibody Y198


Specifications Citations (1) Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA303679 Rabbit monoclonal antibody against Raf-1(Y198) 100ul $325 In Stock
LC419048 RAF1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Serine 338-339 of human Raf was used as immunogen.
Clone NameY198 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1:50-100; ICC: 1:50; IP: 1:100
Predicted MW Explanation 73 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified

Reference Data

Target NameHomo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1)
Alternative Namec-Raf; CMD1NN; CRAF; NS5; Raf-1
Database LinkNP_002871
Entrez Gene 5894 Human
Entrez Gene 110157 Mouse
Entrez Gene 24703 Rat
FunctionThis gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq].
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayVascular smooth muscle contractionVEGF signaling pathwayFocal adhesionMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Raf1 antibody [Y198]; Anti-Raf1 antibody [Y198] at 1/500 dilution + NIH 3T3 cell lysate.Predicted band size : 73 kDa.Observed band size : 74 kDa .

WB Image
Figure from citation: Western blot analysis of RAF-1 protein expression by using anti-RAF1 antibody in miR-7 precursor transfected HCT116 cells (A), SW480 cells (C) and HT29 cells (E) or in miR-7 inhibitor-transfected HCT116 cells (B), SW480 cells (D) and HT29 cells (F). Dilution: 1:1000 View Citation

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Raf1 antibody [Y198]; TA303679, at a 1/100 dilution, staining human Raf1 in colon carcinoma by Immunohistochemistry, Paraffin embedded tissue


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