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Anti-PTPN1 Phospho Antibody EP1841Y
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Also for PTPN1 (NM_002827)
|A synthetic peptide corresponding to residues surrounding serine 386 of human PTP1B was used as an immunogen. This antibody detects both phosphorylated and nonphosphorylated PTP1B.|
||WB: 1:1000; IHC: 1:50; ICC: 1:50; FC: 1:20
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1)|
|The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]. |
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Western blot analysis on (A) HeLa cell lysate (B) HepG2 cell lysate (C) Jurkat cell lysate using anti-PTP1B RabMAb (TA303678), dilution 1:2000.
Immunohistochemical analysis of paraffin-embedded human tonsils using anti-PTP1B RabMAb. (cat. #2257).