OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-PTPN1 antibodies

Anti-PTPN1 PHOSPHO Antibody EP1838Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303677
  • Rabbit monoclonal antibody against PTP1B Phospho (pS50) (EP1838Y ) (phospho-specific)
100ul 325 3-7 Days
Add to Shopping Cart
spacer
WB(1)
spacer
Also for PTPN1 (NM_002827)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surround Serine 50 of human PTP1B was used as an immunogen. This antibody detects PTP1B phosphorylated at Serine 50.
Clone NameEP1838Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2500 - 1:5000
Predicted MW Explanation 50 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1
Alternative NamePTP1B
Database LinkNP_002818
Entrez Gene 5770 Human
FunctionThe protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq].
Related PathwayTransmembranePhosphataseDruggable Genome Adherens junctionInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PTP1B (phospho S50) antibody [EP1838Y]; All lanes : Anti-PTP1B (phospho S50) antibody [EP1838Y] at 1/5000 dilution.Lane 1 : Hela cell lysate - untreated cells.Lane 2 : Hela cell lysate - treated with Calyculin A.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 50 kDa.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title