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Anti-PTPN1 PHOSPHO Antibody EP1839Y
Also for PTPN1 (NM_002827)
|A phospho specific peptide corresponding to residues surrounding Serine 352 of human PTP1B were used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2500 - 5000; IHC: 1:100; IP: 1:40
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens protein tyrosine phosphatase, non-receptor type 1 (PTPN1), transcript variant 1|
|The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq]. |
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Western blot - PTP1B (phospho S352) antibody [EP1839Y]; All lanes : Anti-PTP1B (phospho S352) antibody [EP1839Y] at 1/5000 dilution.Lane 1 : Hela cell lysates (untreated).Lane 2 : Hela cell lysates (treated with Calyculin A).Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP conjugated at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 50 kDa.