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Home Antibody All anti-PSEN2 antibodies

Anti-PSEN2 PHOSPHO Antibody EP2613Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303671
  • Rabbit monoclonal antibody against Presenilin 2 Phospho (pS327) (EP2613Y ) (phospho-specific)
100ul 325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 327 of human Presenilin 2 was used as an immunogen. This antibody detects Presenilin 2 phosphorylated on serine 327.
Clone NameEP2613Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; IP: 1:10
Predicted MW Explanation 50 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens presenilin 2 (PSEN2), transcript variant 1
Alternative NameAD3L; AD4; CMD1V; PS2; STM2
Database LinkNP_000438
Entrez Gene 5664 Human
Entrez Gene 19165 Mouse
Entrez Gene 81751 Rat
FunctionAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq].
Related PathwayTransmembraneProteaseDruggable Genome Notch signaling pathwayAlzheimer's disease

* Availability is in business days
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WB Image
Western blot - Presenilin 2 (phospho S327) antibody [EP2613Y]; All lanes : Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] at 1/5000 dilution.Lane 1 : HeLa cell lysates un-treated.Lane 2 : HeLa cell lysates treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 23 kDa .

 

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