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Anti-PSEN2 PHOSPHO Antibody EP2613Y
Also for PSEN2 (NM_000447)
|A phospho specific peptide corresponding to residues surrounding serine 327 of human Presenilin 2 was used as an immunogen. This antibody detects Presenilin 2 phosphorylated on serine 327.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; IP: 1:10
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens presenilin 2 (PSEN2), transcript variant 1|
|AD3L; AD4; CMD1V; PS2; STM2|
Entrez Gene 5664 Human
Entrez Gene 19165 Mouse
Entrez Gene 81751 Rat
|Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq]. |
|TransmembraneProteaseDruggable Genome Notch signaling pathwayAlzheimer's disease|
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Western blot - Presenilin 2 (phospho S327) antibody [EP2613Y]; All lanes : Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] at 1/5000 dilution.Lane 1 : HeLa cell lysates un-treated.Lane 2 : HeLa cell lysates treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 23 kDa .