A phospho specific peptide corresponding to residues surrounding serine 327 of human Presenilin 2 was used as an immunogen. This antibody detects Presenilin 2 phosphorylated on serine 327.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq].
Related Pathway
Delta-Notch Signaling Pathway
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Western blot analysis on<br> HeLa cell lysates using anti- Phospho Presenilin 2 (pS327) RabMAb (TA303671), dilution 1:5,000. Cells were either (A) untreated (B) treated with AP.
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