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Anti-PSEN2 Antibody EP1515Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Presenilin 2 (EP1515Y )
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human Presenilin 2 was used as an immunogen.
Clone NameEP1515Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IP Suggested DilutionsWB: 1:20000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250; IP: 1:50
Predicted MW Explanation 50 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens presenilin 2 (PSEN2), transcript variant 1
Alternative NameAD3L; AD4; CMD1V; PS2; STM2
Database LinkNP_000438
Entrez Gene 5664 Human
Entrez Gene 19165 Mouse
Entrez Gene 81751 Rat
FunctionAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq].
Related PathwayTransmembraneProteaseDruggable Genome Notch signaling pathwayAlzheimer's disease

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Western blot - Presenilin 2 antibody [EP1515Y]; Anti-Presenilin 2 antibody [EP1515Y] at 1/200000 dilution + PC-12 cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 50 kDa.Observed band size : 23 kDa .
Western blot - Presenilin 2 antibody [EP1515Y]; Anti-Presenilin 2 antibody [EP1515Y] at 1/1000 dilution (for 16 hours at 4°C) + Human HeLa cells - whole cell lysate at 30 ug.Secondary.An HRP-conjugated Goat anti-rabbit IgG at 1/2000 dilution.developed using the ECL technique.Performed under reducing conditions.Predicted band size : 50 kDa.Observed band size : 24 kDa .Exposure time : 1 minute
Immunohistochemistry (Paraffin-embedded sections) - Presenilin 2 antibody [EP1515Y]; Ab51249 (1:50) staining human Presenilin 2 in human kidney tissue by immunohistochemistry using paraffin embedded tissue.
Immunoprecipitation - Presenilin 2 antibody [EP1515Y]; TA303670 Immunoprecipitating Presenilin 2 in human HeLa whole cell lysate. 200ug of cell lysate was incubated with undiluted primary antibody and matrix (Protein G) for 1 hour at 4°C. For western blotting TA303670 (1/1000) was used to confirm successful immunoprecipation.


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