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Home Antibody All anti-PLCG1 antibodies

Anti-PLCG1 PHOSPHO Antibody EPR2610Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303647
  • Rabbit monoclonal antibody against PLC ? 1 Phospho (pY771) (EPR2610Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for PLCG1 (NM_002660)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 771 of human PLC?1 was used as an immunogen. This antibody detects PLC?1 phosphorylated on tyrosine 771.
Clone NameEPR2610Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000
Predicted MW Explanation 149 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1
Alternative NameNCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Database LinkNP_002651
Entrez Gene 5335 Human
FunctionThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Phospholipase C gamma 1 (phospho Y771) antibody [EPR2610Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y771) antibody [EPR2610Y] at 1/20000 dilution.Lane 1 : Jurkat cell lysate (without pervanadate).Lane 2 : Jurkat cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 149 kDa.Observed band size : ~155 kDa .

 

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