Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), transcript variant 2
Synonyms:
PAKalpha
Immunogen
A phosphor-specific peptide corresponding to residues surrounding Serine 20 on human PAK1 was used as an immunogen. This antibody recognized PAK1 phosphorylated at Ser20.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-PAK1 (pS20) RabMAb (TA303625), 1:2000 dilution. Cells were either (A) untreated (B) treated with AP
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