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Home Antibody All anti-MYLK antibodies

Anti-MYLK Antibody EP1458Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303608
  • Rabbit monoclonal antibody against MLCK (EP1458Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC409331) , 20ug
100ul 325 In Stock
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IHC(1)
IF(1)
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Also for MYLK (NM_053031)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminal of human MLCK protein was used as an immunogen.
Clone NameEP1458Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC, IF Suggested DilutionsWB: 1:5000 -10,000; IHC: 1:100 - 250; ICC: 1:100 - 250; FC: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens myosin light chain kinase (MYLK), transcript variant 7
Alternative NameAAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK
Database LinkNP_444259
FunctionThis gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq].
Related Pathway
Focal Adhesion

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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myosin light chain kinase antibody [EP1458Y]; Immunohistochemical analysis of paraffin embedded human smooth muscle, using TA303608, at 1/100 dilution.
IF Image
Immunocytochemistry/ Immunofluorescence - Myosin light chain kinase antibody [EP1458Y]; Immunofluorescent staining of SH-SY5Y cells, using TA303608, at 1/50 dilution.

 

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