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Home Antibody All anti-KIT antibodies

Anti-KIT Antibody Y145

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SKU Description Amount Price Availability*  
TA303564
  • Rabbit monoclonal antibody against C-KIT (CD117), C-Term(Y145)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424857) , 20ug Explanation
100ul $325 3-7 Days
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IHC(6)
FC(2)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus (cytoplasmic domain) of human c-Kit was used as an immunogen. The antibody does not cross-react with other CSF-1/PDGF receptor family member.
Clone NameY145 IsotypeRabbit IgG
Species ReactivityHuman, Marmoset (common) (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC, FC Suggested DilutionsWB: 1:1,000; IHC: 1:50-100
Predicted MW Explanation 145kDa
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1
Alternative NameC-Kit; CD117; PBT; SCFR
Database LinkNP_000213
Entrez Gene 3815 Human
FunctionThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayProtein KinaseES Cell Differentiation/IPSTransmembraneStem cell - PluripotencyAdult stem cellsEmbryonic stem cellsDruggable Genome Cytokine-cytokine receptor interactionEndocytosisHematopoietic cell lineageMelanogenesisPathways in cancerAcute myeloid leukemiaMore Pathways >>

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TA303564 showing positive staining in Lung adenocarcinoma tissue.
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TA303564 showing positive staining in Glioma tissue
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TA303564 showing positive staining in Seminoma tissue
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TA303564 showing positive staining in Breast carcinoma tissue.
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TA303564 showing positive staining in Ovarian carcinoma tissue.
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IHC-P image of c-Kit (TA303564) staining on adult marmoset testis. The sections were fixed in Formaldehyde and underwent heat mediated antigen retrieval, using Dako antigen retrieval solution. The sections were then blocked in 5% milk for 30 mins at 25°C. The primary antibody was added at a 1:100 dilution, and then incubated for 18 hours at 4oC. Dapi was used to stain the nuclei (blue).
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Flow cytometric analysis of permeabilized  Hela cells using TA303564 at 1/350 RabMAb (red)  or a rabbit IgG (negative) (green).
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Flow cytometric analysis of permeabilized K562  cells using TA303564 at 1/350 RabMAb (red) or a rabbit IgG (negative) (green).
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