A synthetic peptide corresponding to the C-terminal residues of human Jak3 was used as an immunogen.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone Name
Polyclonal
Isotype
Rabbit IgG
Species Reactivity
Human, Mouse
Concentration
Purification
Guaranteed Application *
WB
Suggested Dilutions
WB: 1:2000
Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq].
Related Pathway
Jak-STAT signaling pathway
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