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Home All anti-INPP5D antibodies

Anti-INPP5D Antibody EP378Y

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA303547
  • Rabbit monoclonal antibody against SHIP(EP378Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417234) , 20ug
100µl $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
30ul
$100
$50*
In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)
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Also for INPP5D (NM_005541)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Clone NameEP378Y IsotypeRabbit IgG
Species ReactivityHuman Concentration
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50,000; IHC: 1:100-250; FC: 1:20; IP: 1:50
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 2
Alternative Namehp51CN; SHIP; SHIP-1; SHIP1; SIP-145
Database LinkNP_005532
FunctionThis gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Related Pathway
Hemostasis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on Daudi cell lysate using anti-SHIP RabMAb (TA303547), dilution 1:50,000
IHC Image
Immunohistochemical staining of paraffin-embedded human spleen using anti-SHIP RabMAb (TA303547).

 

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